Micro-Splitter Valves

  • For Interfacing LC-MS Systems
  • Adjustable Split Stream Flow Rates
  • Medium and High Pressure Versions
Upchurch Scientific® offers a line of Micro-Splitter Valves designed to accurately split and control a low-flow stream off a single incoming supply.

The biocompatible Medium Pressure Micro-Splitter Valves are perfect for LC-MS and other multidetector systems and fraction collectors. The ideal placement of these valves is on the effluent side of the detector flow cell, at a maximum pressure of 800 psi (55 bar). Choose between 1/4-28 and 10-32 threaded versions. A valve is also available to accommodate applications involving capillary tubing.

The High Pressure Micro-Splitter Valves are designed to operate successfully up to 4,000 psi (276 bar). These products are well suited for running two analytical devices in parallel. The High Pressure Capillary Micro-Splitter Valves may also be used to adapt an analytical HPLC system to handle microbore applications.

Our Graduated Valves offer many of the benefits and features of our original Micro-Splitter Valves, plus the ability to adjust and set the split flow to repeatable settings. This allows documentation of settings and the resulting flow rates for easier method development. The graduations also make it easier to employ the valve in a system used to run multiple analyses that require different split flow rates. Choose from regular High Pressure and Capillary versions.

All Micro-Splitter Valves have been tested at flow rates to 100 mL/min., with a maximum resulting pressure drop of only 45 psi (3.1 bar).

Micro-Splitter Valve Applications & Notes

Back Pressure Considerations


Our Micro-Splitter Valves are designed to work when both effluent flow path pressures are nearly identical. However, the split flow path will often have higher back pressure than the waste flow path, making it hard to achieve any split flow at all. There are two possible solutions. Place a back pressure regulator on the waste flow path that is equal to or slightly greater than the pressure on the split flow path. Or, switch the two effluent pathways such that the split flow pathway is attached to the "waste" port on the valve and the waste flow pathway is attached to the "split" port on the valve.

Prime/Purge Valve

Air within the pump head can cause noisy pump operation and flow instability. Solve this problem by placing a High Pressure Micro-Splitter Valve or High Pressure Universal Prime/Purge Valve inline between the pump and the injector valve. You can then safely divert pump flow to a waste container at a sufficient rate to dislodge the air. Remove air from the solvent line leading to the pump with a Low Pressure Prime/Purge Valve.

Multi-Column and Detector Systems

If your work require analyses with multiple columns and detectors that use the same mobile phase, so install one of our High Pressure Micro-Splitter Valves after your injector. A single injection can then be split to two separate columns and detector systems, at two different flow rates. This economical set-up eliminates the need for an additional pump and injector valve, while allowing data to be obtained simultaneously.

Post-Detector Interfacing

Use a Medium Pressure Micro-Splitter Valve to route fluid exiting an initial detector to other devices, such as a mass spectrometer and a fraction collector. The valve will split and reduce the flow rate to that required for MS interfacing, while diverting the remainder of the flow to the collector.

Other Applications

These valves are also suited for other applications, such as adapting a standard HPLC system to handle microbore analyses.

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Item #

Item Name

Type

Thread Size

Internal Volume (Closed)

Internal Volume (Fully Open)

Max. Operating Pressure

Min. Split Flow Rate

List Price

M-405S

Micro-Splitter Vlv 6-32 SS

High Pressure Capillary

11963|11841

1.2 µL

2.4 µL

4000 psi | 276 bar

4.8 µL/min

$151.11
P-450

Micro-Splitter vlv Assy 1/4-28

Medium Pressure

46756

2.1 µL

4.1 µL

800 psi | 55 bar

2 µL/min

$71.98
P-451

Micro-Splitter vlv Assy 10-32

Medium Pressure

11963

1.2 µL

2.8 µL

800 psi | 55 bar

2 µL/min

$65.63
P-452

Micro-Split Vlv Asy 10-32/6-32

Medium Pressure Capillary

11963|11841

1.2 µL

2.4 µL

800 psi | 55 bar

2 µL/min

$71.98
P-460S

Micro-Split Vlv 10-32 Hi Press

High Pressure

11963

1.2 µL

2.8 µL

4000 psi | 276 bar

4.8 µL/min

$130.41
P-460T

Stream Split Hi Press Titanium

High Pressure

11963

1.2 µL

2.8 µL

4000 psi | 276 bar

4.8 µL/min

$179.06
P-470

Micro-Splitter vlv 10-32 Grad

High Pressure Graduated

11963

1.2 µL

2.8 µL

4000 psi | 276 bar

4.8 µL/min

$395.37
M-472

Micro-Splitter 10-32/6-32 Grad

High Pressure Capillary Graduated

11963|11841

1.2 µL

2.4 µL

4000 psi | 276 bar

4.8 µL/min

$407.79