TARGA columns and cartridges are ideal for applications requiring an absence of secondary solute-silanol interaction. Basic and acidic drugs and peptides can be chromatographed efficiently with little or no buffer. Targa columns are particularly well suited for LC/MS applications where acetic acid or formic acid can be substituted for TFA resulting in significant increase in signal. While TFA is not required, it does not preclude its use on TARGA columns. TARGA exhibits extremely fast equilibration kinetics from high to low organic phase compositions. It works well in 100% aqueous conditions for hydrophilic applications also.